Re-Penetrator is a pornographic spoof of H.P Lovecraft’s 80’s horror flick Re-Animator. Re-Penetrator is the story of a stripper (Joanna Angel), who after being dead for twenty years, is resurrected back to life by a perverted mad scientist (Dr. Breast). Dr. Breast vaginally injects the long-dead, but exquisitely preserved, exotic dancer with special serum so the re-penetrated corpse will return from the VIP room in hell and crave nothing but sex. After he injects her with a gooey green potion the stripper awakens with an insatiable craving for balls, and she fucks the mad scientist from the gurney to the grave.
奈杰尔（休•格兰特 Hugh Grant 饰）陷入了七年之痒的婚姻中。他和妻子菲奥纳（克里斯汀•斯科特•托马斯 Kristin Scott Thomas饰）决定乘坐游轮前往印度旅游，尝试改变糟糕的关系。船上，他遇见了瘫痪作家奥斯卡（彼德•考约特 Peter Coyote 饰）和他的美艳妻子咪咪（埃玛纽埃尔•塞纳 Emmanuelle Seigner饰）。奥斯卡似乎要把他和咪咪之间的异常关系告诉陌生人奈杰尔。
奥斯卡认识咪咪之初，两人爱得死去活来，情欲之火熊熊燃烧。然而咪咪摄人的魅力只让奥斯卡着迷了一段不长的时间。他开始厌倦，尽管咪咪为了他堕胎、割除子宫、对他一往情深，奥斯卡还是残忍的把她支走。一场车祸后，躺在医院的奥斯卡却赫然发现，咪咪就站在他的病床前，怒不可遏的把他拖下病床，奥斯卡终身残废。
他们继续生活在一处。咪咪从来没停止过对奥斯卡的虐待，二人却还相爱。当咪咪遇上菲奥纳，心中燃起了奇妙的爱火，二人相拥而舞。最后，奥斯卡却对着咪咪扣下了扳机。
